Top2b
Web在Top2b基因目的exons两侧分别插入loxP位点。该flox小鼠可与组织特异性Cre工具鼠交配，获得在特定细胞类型或组织中敲除Top2b基因的小鼠模型。 Web11. dec 2012 · さらに、 Top2b の心筋細胞特異的ノックアウトマウスは、ドキソルビシンを投与しても進行性の心不全を発症しないことから、ドキソルビシンによる心臓毒性は心 …
Top2b
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WebNeuronal activity induces topoisomerase IIβ (Top2B) to generate DNA double-strand breaks (DSBs) within the promoters of neuronal early response genes … Webnpm1 parp1 ncl hspa4 top2b tle1 nono rad50 : parp1 src polr2a camk2d hes1 nono crebbp kat2b : copb2 cope copz1 arf1 arcn1 copa copb1 copg1 : cog7 cog2 cog1 cog3 cog8 cog4 cog5 cog6 : cog7 cog2 cog1 cog3 cog8 cog4 cog5 cog6 : eif2s1 xrcc6 xrcc5 eif2s2 eif2s3 prkdc ilf2 ilf3 : tbkbp1 hsp90aa1 hsp90ab1 traf2 cdc37 tank azi2 tbk1
Web12. apr 2024 · Original Concentration: 120µg/mL. Applications: Positive Control; Immunogen; SDS-PAGE; WB. (May be suitable for use in other assays to be determined by the end user.) Predicted isoelectric point: 8.7. Predicted Molecular Mass: 27.5kDa. Accurate Molecular Mass: 30kDa as determined by SDS-PAGE reducing conditions. WebThrough molecular move simulations, us show here that growing plectonemes resulting from transcription-induced supercoiling have the aptitude to actively push cohesin rings along chromatin filaments. The pushing direction is such that within each topologically associating domain (TAD) cohesin rings fo …
Web4. nov 2024 · In this review, we provide an updated overview of TOP2A and TOP2B in the regulation of chromatin topology and transcription, and discuss the recent discoveries … WebTamoxifen诱导Cre-ERT2小鼠 使用指南. Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物） …
Webences were seen in the transcripts of TOP2b in parent and EDRP. However, TOP2b was found to be significantly down-regulated in LDRP of both K562 and THP-1 cell line (Fig. 4f and Supporting Information, Fig. 4b). Similarly, HL-60/MX-2 cells also showed downregulation of TOP2b (Supporting Information, Fig. 4c). We further examined the drug …
WebTOP2B 抗体. TOP2B ELISA试剂盒. TOP2B 蛋白. TOP2B 多肽. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during … church clothes for guysWebKontakt. Top 2B GmbH. Flecken 4. 6023 Rothenburg. T 041 281 07 02. F 041 280 07 08. mail (at)top2b.ch. Alle mit * markierten Felder sind Pflichtfelder! Name*. de typemachineWeb28. feb 2024 · TOP2A and TOP2B, which efficiently remove Sc +, have been reported in mitochondria of human cells, and in bovine mitochondria and mouse brain and sperm … de\u0026i activities at workWeb1. mar 2011 · 3QX3. PubMed Abstract: Type II topoisomerases (TOP2s) resolve the topological problems of DNA by transiently cleaving both strands of a DNA duplex to form … de\u0026s abbey wood postcodeWeb15. máj 2007 · Top2b activity has recently been shown to play a key role in transcription by creating transient double-stranded DNA breaks in the promoter regions of a number of genes . For example, estrogen-bound ERα directs an activating complex that includes Top2b, polyADP-ribose polymerase 1, and other factors typically associated with DNA repair to a ... de\u0026s functional competence frameworkWeb31. aug 2016 · Type II DNA topoisomerases (TOP2) regulate DNA topology by generating transient double stranded breaks during replication and transcription. Topoisomerase II … de\u0026s abbeywood postcodeWebDefects in TOP2B may be involved in global developmental delay with autism spectrum disorder (ASD) 2 publications. B-cell immunodeficiency, distal limb anomalies, and urogenital malformations (BILU) 3 publications. Note. The disease is caused by variants affecting the gene represented in this entry; de\u0026i initiatives in the workplace