Hydroxytamoxifen是什么

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August undefined, 2024

WebAfimoxifene C26H29NO2 CID 449459 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety ... http://www.larc.tsinghua.edu.cn/post/971/31

Tamoxifen - frwiki.wiki

Web3 mrt. 2012 · The antiestrogenic effect of tamoxifen is mainly attributable to the active metabolites endoxifen and 4-hydroxytamoxifen. This effect is assumed to be concentration-dependent and therefore quantitative analysis of tamoxifen and metabolites for clinical studies and therapeutic drug monitoring is increasing. We investigated the … Web4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM). 靶点活性. Estrogen Receptor:3.3 nM. 体外活性. 4-Hydroxytamoxifen can inhibit the [3H]estradiol … thipburee hotel\\u0026resort

Afimoxifene - Wikipedia

WebMoreover, the metabolic conversion ratio of 4-hydroxytamoxifen to N-desmethyltamoxifen in female rats was roughly onefold and the ratio of 4-hydroxytamoxifen to endoxifen conversion was 4- to 5-fold. However, our previous study demonstrated that the percentage of 4-hydroxytamoxifen conversion in male rats is only 26% . WebTamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast … WebBiochem/physiol Actions. 4-Hydroxytamoxifen (4-HT) is the active metabolite of tamoxifen which binds estrogen receptors (ER) and estrogen-related receptors (ERR) with … thiper

4-Hydroxytamoxifen Estrogen …

Web(Z)-4-Hydroxytamoxifen ( (Z)-4-OHT, trans-4-Hydroxytamoxifen, 4-Monohydroxytamoxifen) is a selective modulator of estrogen receptor (SERM) with IC50 of 3.3 nM for the [ 3 H]oestradiol binding to oestrogen receptor. CAS No. 68047-06-3 Purity & Quality Control Other Estrogen/progestogen Receptor Products Licochalcone A New Web然而他莫昔芬确会促进ER的AF1（Activation function 1）结构域的激活，促进微弱的转录激活，进而导致雌激素信号的不完全阻止。. 在经过临床内分泌治疗后，乳腺癌细胞会发 … thiperiodiska systemetWebhydroxytamoxifen-induced的中文翻译，hydroxytamoxifen-induced是什么意思，怎么用汉语翻译hydroxytamoxifen-induced，hydroxytamoxifen-induced的中文意 … thiphasone vongnarath

"Web用(Z)-4-hydroxytamoxifen对已接受0 ~ 2 μg雌二醇皮下注射的未成熟大鼠灌胃。与给予雌二醇的对照组比，这两种化合物与子宫湿重的减少呈剂量相关性。以每天1 μg的剂 … " - Hydroxytamoxifen是什么

Hydroxytamoxifen是什么

Figure 4. Induction of Cre recombination by 4-hydroxy-tamoxifen…

WebChemicalBook 为您提供枸橼酸他莫昔芬(54965-24-1)的化学性质，熔点，沸点，密度，分子式，分子量，物理性质，毒性，结构式，海关编码等信息，同时您还可以浏览枸橼酸他 … Web4-Hydroxytamoxifen (4-OHT, Sigma-Aldrich) was dissolved at 20 mg/ml in ethanol by shaking at 37℃ for 15 min and was then aliquoted and stored at -20℃ for up to several …

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WebFerrocifen (20, Fig. 4), like the corresponding Ru compound described above, is an organometallic derivative of the breast cancer drug tamoxifen.The ferrocene analog of … Web( Z )-4-Hydroxytamoxifen is a Tamoxifen (Cat. No. 0999) metabolite; that exhibits greater potency than the parent compound. ( Z )-4-Hydroxytamoxifen also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ~25-fold higher specificity than wtCas9.

Web14 jan. 2024 · 4-羟基三苯氧胺（10,100 nM）能够抑制 [3H]雌二醇与人体8 S雌激素受体的结合 [1]。. 4-羟基三苯氧胺激活内含肽连接的无活性Cas9，减少脱靶的CRISPR介导的基 … Web一、品系介绍：Cre-ERT2小鼠是一类含有雌激素受体（estrogen receptor，ER）的配体结合区突变体（ERT）与Cre重组酶的融合蛋白表达的小鼠。Cre-ERT2在无Tamoxifen诱 …

WebHowever, long-term usage of tamoxifen has been linked to increased risk of developing endometrial cancer in women. One of the suggested pathways leading to the potential toxicity of tamoxifen involves its oxidative metabolism to 4-hydroxytamoxifen, which may be further oxidized to an electrophilic quinone methide. Webα-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts [1] . Room temperature in …

Web4-Hydroxytamoxifen 4-羟基他莫昔芬 (Z)-4- (1- [4- (二甲基氨基乙氧基)苯基]-2-苯基-1-丁烯)苯酚它是雌激素受体拮抗剂解析看不懂？免费查看同类题视频解析查看解答相似问题 …

Web960化工网为您提供4-羟基他莫昔芬 68047-06-3化学品安全技术说明书，4-羟基他莫昔芬msds，包含高清的4-羟基他莫昔芬 68047-06-3结构式图片,包括中文名称、英文名称、别名、分子式、分子量、熔点、密度、蒸汽压、溶解性、外观与性状、用途等说明信息，找化学品安全技术说明书上960化工网，全国免费 ... thipenWebCAS Number Chemical Formula Molecular Weight Purity Grade 68047-06-3 C 26 H 29 NO 2: 387.51 ≥94% Reagent grade thiphaine houotWeb4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of … thiphapluattructuyen.netWeb14 okt. 2024 · tdtomato荧光蛋白的激发光波长是多少. tdtomato荧光蛋白是属于一种红色荧光蛋白，可以用520nm的绿光激发，发射出的荧光为红色。. tdtomato荧光蛋白的激发光谱 … thiphene concaWeb23 mrt. 2005 · 4-Hydroxytamoxifen-Mediated Apoptosis in Multiple Myeloma Cells Requires a Mitochondrial-Dependent Death Pathway. It has been suggested that for one multiple myeloma cell line tamoxifen treatment induces an up-regulation of Fas expression and that tamoxifen-induced apoptosis requires the death receptor extrinsic pathway . thipe epiWebEndoxifen wordt gezien als de belangrijkste metaboliet, mede omdat de steady-state serumconcentratie van endoxifen ongeveer vijfmaal hoger is dan de concentratie van 4-hydroxytamoxifen. De behandeling met tamoxifen – waarbij nu iedereen in principe 20 mg krijgt – kan mogelijk optimaler door individueel te doseren op basis van de concentraties … thipinWeb生物活性 for (Z)-4-Hydroxytamoxifen(Z)-4-Hydroxytamoxifen is an estrogen receptor antagonist (IC 50 = 27 μM).(Z)-4-Hydroxytamoxifen is a Tamoxifen (Cat. No. 0999) … thiphp